Effect of roflumilast (0.03-3 mg/kg po) and dexamethasone (0.3 mg/kg po) dosed orally 1 hour before LPS (0.03 mg/kg iv) administration on subsequent TNF-α release in vivo (sampled 1 hour post LPS) in rat

Data are mean ± sem, n=8.  * p<0.05, ** p<0.01, *** p<0.001 significantly different from vehicle.  Data analysed with Kruskal-Wallis ANOVA and Dunn’s multiple comparisons tests.